PFAPA syndrome: a review on treatment and outcome
نویسندگان
چکیده
The syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA syndrome) is the most common cause of periodic fever in childhood. The current pharmacological treatment includes corticosteroids, which usually are efficacious in the management of fever episodes, colchicine, for the prophylaxis of febrile episodes, and other medication for which efficacy has not been proven so far. Tonsillectomy is an option for selected patients. Usually PFAPA syndrome resolves during adolescence, but there is increasing evidence that this condition may persist into adulthood.
منابع مشابه
Effect of adenotonsillectomy in PFAPA syndrome.
OBJECTIVE To assess the benefits of adenotonsillectomy in the treatment of pediatric patients with PFAPA (periodic fever, aphthous ulcers, pharyngitis, and adenitis) syndrome. DESIGN Prospective case series. SETTING Tertiary care pediatric hospital. PATIENTS Pediatric patients meeting criteria for PFAPA syndrome. INTERVENTION Tonsillectomy with or without adenoidectomy. MAIN OUTCOME M...
متن کاملPeriodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome.
Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome, the most common periodic disorder of childhood, presents with the cardinal symptoms of periodic fever, aphthous stomatitis, pharyngitis, and adenitis typically before age 5. This review presents the recent literature on PFAPA and summarizes key findings in the pathogenesis, evaluation, and treatment of the disease....
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Methods We conducted a retrospective study on patients with clinical diagnosis of PFAPA syndrome followed at a tertiary center from January 1993 to August 2010. Clinical and laboratory parameters have been evaluated at onset and during the follow-up. Disease remission was considered as the absence of symptoms for at least one year. Disease outcome in patients who underwent tonsillectomy was com...
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OBJECTIVE The periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is a nonhereditary idiopathic febrile syndrome belonging to the group of autoinflammatory diseases. No longtime sequel was reported in this disease. Early diagnosis can lead physicians to treatment of this disorder with a short course steroid application and provide satisfaction of the patient'...
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